| Date | Opponent | Location | Time/Result |
|---|---|---|---|
| 9/4/21 | MIA Redhawks | Nippert Stadium | 49 - 14 (W) |
| 9/11/21 | Murray State | Nippert Stadium | 42 - 7 (W) |
| 9/18/21 | Indiana Hoosiers | Memorial Stadium | 12:00 pm |
| 10/2/21 | Notre Dame | Notre Dame Stadium | 02:30 pm |
| 10/8/21 | TEM Owls | Nippert Stadium | 07:00 pm |
| 10/16/21 | UCF Knights | Nippert Stadium | TBA |
| 10/23/21 | Navy Midshipmen | Navy-Marine Corps Memorial Stadium | 12:00 pm |
| 10/30/21 | Tulane Green Wave | Yulman Stadium | TBA |
| 11/6/21 | TUL Hurricane | Nippert Stadium | TBA |
| 11/12/21 | USF Bulls | Raymond James Stadium | 06:00 pm |
| 11/20/21 | SMU Mustangs | Nippert Stadium | TBA |
| 11/27/21 | ECU Pirates | Dowdy–Ficklen Stadium | TBA |